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Re: ? mutation found

Posted by PHILIP on March 02, 2001 at 12:48:16:

In Reply to: Re: ? mutation found posted by Sebastiaan Overeem on March 02, 2001 at 00:06:12:

Thanks for responding, I went down to the library and it was just like you said (the abstract was definately confusing for me) If you are not to pressed for time did you understand this article (I couldn't find it at the Health scieces library)Waleh NS, SRI International, 333 Ravenswood Ave., CA 94025

Hypocretins 1 and 2 (also called orexins A and B, respectively). . . . . . . . . . . These two peptides are derived from a single precursor molecule called prepro-hypocretin, also known as prepro-orexin. We have cloned a 450 bp fragment from the 5'-flanking region of the human prepro-hypocretin gene and demonstrated that this fragment has promoter activity in vitro. Deletions at the 5' end from -450 to -188 reduced the promoter activity by approximately 50%. Further deletion from the 5'-end to -69 almost completely abolished promoter activity. The 450 bp fragment contains a number of potential transcription factor binding sites, including an interferon (IFN) response element. Our studies demonstrate that alpha-IFN strongly inhibits the promoter activity of both 450 and 188 bp fragments in a dose-dependent manner. The inhibitory effect of alpha-IFN is consistent with recent studies which suggest that hypocretin 1/orexin A may be involved in modulating arousal states and with the literature indicating involvement of immune-related molecules in sleep regulation. PMID: 11179675 ,,also is it common for there to be more than one receptor in the promotor region of a gene that controls the rate of production of the product?

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