A great place to start Disorder information source Rated and Reviewed Sleep Links Entrance to all monitored Sleep Forums Search all of Sleepnet.com


Narcolepsy Forum
Posting


Archived Narcolepsy Forum2 viewing only. To post a new topic go to the Narcolepsy Forum Homepage.

MK-667

Posted by phil on August 27, 1999 at 01:30:20:

http://www.cem.msu.edu/~cem181fp/sleep/part2.html
However, treatments with MK - 677 [Fig. 2] somehow stimulate the secretion of GH. For that reason, MK - 677 is called a
GH secretagogue -- a chemical that stimulates production/secretion of another substance. MK-677 is neither a hormone nor a
peptide compound. It, however has been shown to increase GH levels and improve sleep quality for young boys and adults when
taken orally. Recent testing has shown that prolonged high dose treatments of MK-677 (25mg) resulted in a 20% increase in
REM sleep for 18 to 30 year old adults and a 50% increase in REM sleep for older adults. These increases in sleep time were
accompanied by larger pulses of GH secretion at the onset of sleep. Since MK-677was discovered so recently, there is a limited
amount of research on this drug. Testing is now taking place at Merck Laboratories. No side effects of the drug MK-677 are
known; only benefits. WOW. THAT'S NEAT. SO, UH, HOW DOES IT WORK?

The mechanisms by which MK-677 operates are not completely understood at this time. However, a recent study has
identified a new receptor for GHRP and MK-677 in both the pituitary gland and the hypothalamus. This leads us to conclude that
MK-677 actually affects the central nervous system. It is also possible that MK-677, in addition to its power to increase in GH
secretion, simply has a favorable effect on the hormones that regulate sleep for the human body. In either case, it would be
advantageous to study the recently discovered receptor for GHRP and MK-677. The answers to many questions concerning
MK-677 lie in the understanding of this new receptor and its function. Further testing of MK-677 is necessary to look for
long-term side effects, for no short-term side effects have been discovered. But for now, MK-677 seems to be a miracle
treatment for decreased GH secretion as well as sleepless nights.


Follow Ups:


Archived Narcolepys Forum2 viewing only. To post a new topic go to the Narcolepsy Forum Homepage

  • IMPORTANT : Information not intended as medical advice. If you suspect that you have a sleep disorder you should seek care from a qualified professional. Read Terms of Use.
  • The Sleep Forums are not to be used for commercial purposes.
  • Commercial products and services are not endorsed by Sleepnet.com.
  • Sleep Deprivation due to Sleep Apnea and insufficient sleep are common and can present as insomnia, narcolepsy, or idiopathic hypersomnia. In infants and children sleep problems commonly present themselves as ADD or ADHD.


Copyright ©1995-2005 Sleepnet.com., All rights reserved