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Re: Mechanism of narcolepsy...

Posted by charles757 on August 25, 2003 at 09:01:57:

In Reply to: Mechanism of narcolepsy... posted by charles757 on August 21, 2003 at 09:39:26:

Restructrue the questions as follows. Anyway, they are essential as the clue for narcolepsy research and for the direction of treatment in the future.

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Narcoleptic patients usually suffer from daytime sleep attacks every two or three hours, for example, periodical sleep episodes intrude at 9:30am, 11:30am,1:30pm,3:30pm, 6:00pm and/or 8:00pm. It seem like a special ultradian rhythm form for wakefulness-sleep intrusion cycles throughout much of day, like NREM-REM sleep cycles of nocturnal sleep in normal people. The patients can feel refreshed after nap.
Q: ---- Are there any finding to support that hypocretin can rapidly improve its activity to relay information to many areas, even after a short-time sleep, to really restore the ability of stabilizing vigilance state boundary? Or, Is other substances that lead a more important pole in pathology of narcolepsy accumulatively change to trigger sleep episode after maintaining two or more hours of wakefulness? What substances can quickly change their activity after nap to restore wakefulness?

The sleepy feeling involuntarily produce around the inside area of occiput without warning after maintain two or three hours wakefulness. The sleep attacks-generating area is near that of generating yawn.
Q: ----Is narcolepsy caused by an abnormal ultrdian rhythm of sleep-generating pattern due to certain genetic basis, like the sleep pattern of cat?

During nap caused by uncontrollable sleep attacks, narcoleptic patients’ lower jaw often have quick and slight movements to touch upper jaw and hands or legs have a twitch during the transition from sleep to wakefulness.
Q: ----Do you have the same jaw movements? What neurochemistry mechanism causes the lower jaw involuntary activities during the restorative short-time sleep? What is the most important changes in neurochemistry mechanism during the restorative naps?
Best regards,


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